Tobacco Exposure Enhances Human Papillomavirus 16 Oncogene Expression via EGFR/PI3K/Akt/c-Jun Signaling Pathway in Cervical Cancer Cells

High-risk human papillomavirus (HR-HPV) infection is not a sufficient condition for cervical cancer development because most infections are benign and naturally cleared. Epidemiological studies revealed that tobacco smoking is a cofactor with HR-HPV for cervical cancer initiation and progression, ev...

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Main Authors: Juan P. Muñoz, Diego Carrillo-Beltrán, Víctor Aedo-Aguilera, Gloria M. Calaf, Oscar León, Edio Maldonado, Julio C. Tapia, Enrique Boccardo, Michelle A. Ozbun, Francisco Aguayo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-12-01
Colecção:Frontiers in Microbiology
Assuntos:
cervical cancer
papillomavirus
cigarette smoke
signaling
HPV oncoproteins
Acesso em linha:https://www.frontiersin.org/article/10.3389/fmicb.2018.03022/full
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