Dexmedetomidine improved one-lung ventilation-induced cognitive dysfunction in rats

Abstract Background One-lung ventilation (OLV) is widely used in thoracic surgery. However, OLV may also increase CERO2 and aggravate delayed cognitive recovery. Here, we aimed to investigate the effect of dexmedetomidine (DEX) on cognitive function in rats undergoing OLV. Methods Sprague-Dawley rat...

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Autori principali: Mengyun Li, Zhe Jin, Jia Zhan, Yanlin Wang, Kai Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2022-04-01
Serie:BMC Anesthesiology
Soggetti:
Dexmedetomidine
One-Lung Ventilation
CERO2
Cognitive Dysfunction
ERK1/2-CREB-Bcl-2
Accesso online:https://doi.org/10.1186/s12871-022-01658-w
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