Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis

Neurotransmitters have been shown to regulate immune responses, and thereby are critically related to autoimmune diseases. Here we showed that depletion of dopaminergic neurons significantly promoted activation of hepatic iNKT cells and augmented concanavalin A (Con A)-induced liver injury. The supp...

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Main Authors: Rufeng Xue, Huimin Zhang, Jun Pan, Zhiwei Du, Wenjie Zhou, Zhi Zhang, Zhigang Tian, Rongbin Zhou, Li Bai
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018-10-01
Serija:Frontiers in Immunology
Teme:
dopamine
D1-like receptors
hepatitis
iNKT
gut microbes
Online dostop:https://www.frontiersin.org/article/10.3389/fimmu.2018.02398/full
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