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Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis

Neurotransmitters have been shown to regulate immune responses, and thereby are critically related to autoimmune diseases. Here we showed that depletion of dopaminergic neurons significantly promoted activation of hepatic iNKT cells and augmented concanavalin A (Con A)-induced liver injury. The supp...

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Detalhes bibliográficos
Main Authors: Rufeng Xue, Huimin Zhang, Jun Pan, Zhiwei Du, Wenjie Zhou, Zhi Zhang, Zhigang Tian, Rongbin Zhou, Li Bai
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-10-01
Colecção:Frontiers in Immunology
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Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.02398/full
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