The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors

There are many reactive intermediates found in metabolic pathways. Could these potentially toxic molecules be exploited for an organism's benefit? We propose that during certain microbial infections, the production of inherently reactive aldehydes by an infected host is a previously unappreciat...

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Detaylı Bibliyografya
Asıl Yazarlar: K. Heran Darwin, Sarah A. Stanley
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Royal Society 2022-04-01
Seri Bilgileri:Open Biology
Konular:
aldehydes
Mycobacterium tuberculosis
nitric oxide
interferon-gamma
macrophages
innate immunity
Online Erişim:https://royalsocietypublishing.org/doi/10.1098/rsob.220010
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