Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Abstract Background Infections with helminths cause an enormous disease burden in billions of animals and plants worldwide. Large scale use of anthelmintics has driven the evolution of resistance in a number of species that infect livestock and companion animals, and there are growing concerns regar...

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Main Authors: Stephen R. Doyle, Christopher J. R. Illingworth, Roz Laing, David J. Bartley, Elizabeth Redman, Axel Martinelli, Nancy Holroyd, Alison A. Morrison, Andrew Rezansoff, Alan Tracey, Eileen Devaney, Matthew Berriman, Neil Sargison, James A. Cotton, John S. Gilleard
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-03-01
Colecção:BMC Genomics
Assuntos:
Haemonchus contortus
Ivermectin
Drug resistance
Genome sequencing
Population genetics
Genetic mapping
Acesso em linha:http://link.springer.com/article/10.1186/s12864-019-5592-6
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