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Validation of a flow cytometry based chemokine internalization assay for use in evaluating the pharmacodynamic response to a receptor antagonist

<p>Abstract</p> <p>Pharmacodynamic assays are important in clinical trial design to investigate the relationship between drug concentration (pharmacokinetics) and drug "effect' or biological activity. Increasingly flow cytometry is being used to examine the pharmacodynami...

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Detalhes bibliográficos
Main Authors: Lackey Alan, Wyant Timothy, Green Marie
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2008-12-01
Colecção:Journal of Translational Medicine
Acesso em linha:http://www.translational-medicine.com/content/6/1/76
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