Novel Ensemble Feature Selection Approach and Application in Repertoire Sequencing Data

The T and B cell repertoire make up the adaptive immune system and is mainly generated through somatic V(D)J gene recombination. Thus, the VJ gene usage may be a potential prognostic or predictive biomarker. However, analysis of the adaptive immune system is challenging due to the heterogeneity of t...

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Detalhes bibliográficos
Main Authors: Tao He, Jason Min Baik, Chiemi Kato, Hai Yang, Zenghua Fan, Jason Cham, Li Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Genetics
Assuntos:
feature ensemble
VJ gene usage
repertoire sequencing data
high-dimensional data
COVID-19
adaptive immune system
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fgene.2022.821832/full
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