Generalized disequilibrium test for association in qualitative traits incorporating imprinting effects based on extended pedigrees

Abstract Background For dichotomous traits, the generalized disequilibrium test with the moment estimate of the variance (GDT-ME) is a powerful family-based association method. Genomic imprinting is an important epigenetic phenomenon and currently, there has been increasing interest of incorporating...

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Main Authors: Jian-Long Li, Peng Wang, Wing Kam Fung, Ji-Yuan Zhou
Format: Artigo
Jezik:Inglês
Izdano: BMC 2017-10-01
Serija:BMC Genetics
Teme:
Generalized disequilibrium test
Genomic imprinting
Monte Carlo sampling
Qualitative trait
Online dostop:http://link.springer.com/article/10.1186/s12863-017-0560-0
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