Optimising trial designs to identify appropriate antibiotic treatment durations

Abstract Background For many infectious conditions, the optimal antibiotic course length remains unclear. The estimation of course length must consider the important trade-off between maximising short- and long-term efficacy and minimising antibiotic resistance and toxicity. Main body Evidence on op...

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Detalhes bibliográficos
Main Authors: Koen B. Pouwels, Mo Yin, Christopher C. Butler, Ben S. Cooper, Sarah Wordsworth, A. Sarah Walker, Julie V. Robotham
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-06-01
Colecção:BMC Medicine
Assuntos:
Antimicrobial resistance
Design
Randomised trial
Duration of therapy
Antibiotics
Bayesian
Acesso em linha:http://link.springer.com/article/10.1186/s12916-019-1348-z
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