miR-4666-3p and miR-329 Synergistically Suppress the Stemness of Colorectal Cancer Cells via Targeting TGF-β/Smad Pathway

Quiescent caner stem cells are identified as a subpopulation of colon cancer cells in dormant state and possess strong stem-cell like characteristics. Previously, we have identified this subpopulation in colorectal cancer (quiescent colon cancer stem cells, QCCSCs), and find QCCSCs are sensitive to...

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Detalhes bibliográficos
Main Authors: Jun Ye, Jiacai Lei, Qingqing Fang, Yimin Shen, Wenjie Xia, Xiaoge Hu, Qiuran Xu, Hongjun Yuan, Jian Huang, Chao Ni
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-11-01
Colecção:Frontiers in Oncology
Assuntos:
colorectal cancer
miR-4666-3p
miR-329
cancer stem cells
TGF-β/smad
Acesso em linha:https://www.frontiersin.org/article/10.3389/fonc.2019.01251/full
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