Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling

Rapamycin treatment has been shown to increase autophagy activity and activate Akt phosphorylation, suppressing apoptosis in several models of ischemia reperfusion injury. However, little has been studied on the neuroprotective effects on spinal cord injury by activating Akt phosphorylation. We hypo...

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Detalhes bibliográficos
Main Authors: Xi-Gong Li, Jun-Hua Du, Yang Lu, Xiang-Jin Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Medknow Publications 2019-01-01
Colecção:Neural Regeneration Research
Assuntos:
nerve regeneration; rapamycin; mammalian target of rapamycin
mTOR; autophagy; Beclin 1; 3-methyladenine; acute spinal cord injury; apoptosis; Bax; Akt; neural regeneration
Acesso em linha:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=4;spage=721;epage=727;aulast=Li
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