miRNA‐34c Suppresses Osteosarcoma Progression In Vivo by Targeting Notch and E2F

ABSTRACT The expression of microRNAs (miRNAs) is dysregulated in many types of cancers including osteosarcoma (OS) due to genetic and epigenetic alterations. Among these, miR‐34c, an effector of tumor suppressor P53 and an upstream negative regulator of Notch signaling in osteoblast differentiation,...

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Autores principales: Yangjin Bae, Huan‐Chang Zeng, Yi‐Ting Chen, Shamika Ketkar, Elda Munivez, Zhiyin Yu, Francis H. Gannon, Brendan H. Lee
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley 2022-05-01
Colección:JBMR Plus
Materias:
E2F5
miRNA‐34c
Notch
Osteosarcoma
Tumor suppressor
Acceso en línea:https://doi.org/10.1002/jbm4.10623
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