miRNA‐34c Suppresses Osteosarcoma Progression In Vivo by Targeting Notch and E2F

ABSTRACT The expression of microRNAs (miRNAs) is dysregulated in many types of cancers including osteosarcoma (OS) due to genetic and epigenetic alterations. Among these, miR‐34c, an effector of tumor suppressor P53 and an upstream negative regulator of Notch signaling in osteoblast differentiation,...

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Bibliographic Details
Main Authors: Yangjin Bae, Huan‐Chang Zeng, Yi‐Ting Chen, Shamika Ketkar, Elda Munivez, Zhiyin Yu, Francis H. Gannon, Brendan H. Lee
Format: Artigo
Language:Inglês
Published: Wiley 2022-05-01
Series:JBMR Plus
Subjects:
E2F5
miRNA‐34c
Notch
Osteosarcoma
Tumor suppressor
Online Access:https://doi.org/10.1002/jbm4.10623
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