R-spodin2 enhances canonical Wnt signaling to maintain the stemness of glioblastoma cells

Abstract Background As newly identified Wnt enhancer, R-spondin gene family members have been linked to various cancers; however, their role in isocitrate dehydrogenase-wildtype subtype of human glioblastoma (GBM) cells remains unknown. Methods Human U87 and U251 cell lines were used to perform the...

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Main Authors: Si Liu, Kin Pong U, Jieting Zhang, Lai Ling Tsang, Jiawei Huang, Shui Ping Tu, Xiaohua Jiang
Format: Artigo
Jezik:Inglês
Izdano: BMC 2018-10-01
Serija:Cancer Cell International
Teme:
R-spondin2
Glioblastoma
Stemness
Wnt
Cancer stem cells
Online dostop:http://link.springer.com/article/10.1186/s12935-018-0655-3
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