Disruption of Protein Mannosylation Affects Candida guilliermondii Cell Wall, Immune Sensing, and Virulence

The fungal cell wall contains glycoproteins that interact with the host immune system. In the prominent pathogenic yeast Candida albicans, Pmr1 acts as a Golgi-resident ion pump that provides cofactors to mannosyltransferases, regulating the synthesis of mannans attached to glycoproteins. To gain in...

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Main Authors: María J. Navarro-Arias, Tatiana A. Defosse, Karine Dementhon, Katalin Csonka, Erika Mellado-Mojica, Aline Dias Valério, Roberto J. González-Hernández, Vincent Courdavault, Marc Clastre, Nahúm V. Hernández, Luis Antonio Pérez-García, Dhirendra K. Singh, Csaba Vizler, Attila Gacser, Ricardo S. Almeida, Thierry Noël, Mercedes G. López, Nicolas Papon, Hector M. Mora Montes
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Microbiology
Assuntos:
Cell Wall
Virulence
protein glycosylation
Candida guilliermondii
mannosylation pathway
host-fungus interplay
Acceso en liña:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01951/full
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