A novel role of lysophosphatidic acid (LPA) in human myeloma resistance to proteasome inhibitors

Abstract Lysophosphatidic acid (LPA) is a naturally occurring phospholipid that regulates cell proliferation, survival, and migration. However, its role on human multiple myeloma (MM) cells is largely unknown. In this study, we show that LPA, which is highly elevated in MM patients, plays an importa...

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Bibliographic Details
Main Authors: Pan Su, Liuling Xiao, Lingqun Ye, Zhuo Wang, Wei Xiong, Qiang Wang, Xingzhe Ma, Miao Xian, Maojie Yang, Youli Zu, Sai Ravi Pingali, Jianfei Qian, Qing Yi
Format: Artigo
Language:Inglês
Published: BMC 2022-05-01
Series:Journal of Hematology & Oncology
Subjects:
LPA
LPAR2
Multiple myeloma
Proteasome inhibitor
Drug resistance
Online Access:https://doi.org/10.1186/s13045-022-01269-5
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