An Inflammatory Nucleus Pulposus Tissue Culture Model to Test Molecular Regenerative Therapies: Validation with Epigallocatechin 3-Gallate

Organ cultures are practical tools to investigate regenerative strategies for the intervertebral disc. However, most existing organ culture systems induce severe tissue degradation with only limited representation of the in vivo processes. The objective of this study was to develop a space- and cost...

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Main Authors: Olga Krupkova, Marian Hlavna, Julie Amir Tahmasseb, Joel Zvick, Dominik Kunz, Keita Ito, Stephen J. Ferguson, Karin Wuertz-Kozak
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2016-09-01
Series:International Journal of Molecular Sciences
Assuntos:
nucleus pulposus
organ culture model
degenerative disc disease
IL-1β
TNF-α
chondroitinase ABC
epigallocatechin 3-gallate
inflammation
extracellular matrix
Acceso en liña:http://www.mdpi.com/1422-0067/17/10/1640
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