Synthesis of New Quinoline-Piperonal Hybrids as Potential Drugs against Alzheimer’s Disease

Six quinoline-piperonal hybrids were synthesized and evaluated as potential drugs against Alzheimer’s disease (AD). Theoretical analysis of the pharmacokinetic and toxicological properties of the compounds suggest that they present good oral bio-availability and are also capable of penetra...

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Detalhes bibliográficos
Main Authors: Juliana de Oliveira C. Brum, Denise Cristian F. Neto, Joyce Sobreiro F. D. de Almeida, Josélia Alencar Lima, Kamil Kuca, Tanos Celmar C. França, José D. Figueroa-Villar
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-08-01
Colecção:International Journal of Molecular Sciences
Assuntos:
piperonal
quinolines
guanil-hydrazones
acetylcholinesterase
Alzheimer’s disease
Acesso em linha:https://www.mdpi.com/1422-0067/20/16/3944
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