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Comprehensive assessment of genetic sequence variants in the antioxidant 'master regulator' NRF2 in idiopathic Parkinson's disease.

Parkinson's disease (PD) is a complex neurodegenerative disorder influenced by a combination of genetic and environmental factors. The molecular mechanisms that underlie PD are unknown; however, oxidative stress and impairment of antioxidant defence mechanisms have been implicated as major cont...

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Autores principales: Michael Todorovic, Jeremy R B Newman, Jianguo Shan, Steven Bentley, Stephen A Wood, Peter A Silburn, George D Mellick
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2015-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC4444110?pdf=render
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