Dual Inhibition of AChE and BChE with the C-5 Substituted Derivative of Meldrum’s Acid: Synthesis, Structure Elucidation, and Molecular Docking Studies

Alzheimer’s disease (AD) lies in the category of those diseases which are still posing challenges to medicinal chemists, and the search for super-effective drugs for the treatment of AD is a work in progress. The inhibition of cholinesterase is considered a viable strategy to enhance the level of ac...

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מידע ביבליוגרפי
Main Authors: Haroon Mehfooz, Aamer Saeed, Anamika Sharma, Fernando Albericio, Fayaz Ali Larik, Farukh Jabeen, Pervaiz Ali Channar, Ulrich Flörke
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2017-07-01
סדרה:Crystals
נושאים:
Meldrum’s acid derivative
synthesis
crystal study
dual inhibition
AChE and BChE
SAR
Molecular Docking
DFT
גישה מקוונת:https://www.mdpi.com/2073-4352/7/7/211
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