Oxidative stress promotes ventilator-induced lung injury through activating NLRP3 inflammasome and TRPM2 channel

Ventilator has been widely used for life support, but ventilator-induced lung injury (VILI) is still a major problem. Oxidative stress has been considered as a key contributor for VILI, but the specific mechanism remains unclear. The expression of NLRP3 inflammasome in cells and inflammatory factors...

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Detalhes bibliográficos
Main Authors: Xiaona An, Xiaotong Sun, Xiaomei Yang, Dejie Liu, Yonghao Hou, Hongli Chen, Jianbo Wu
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2019-12-01
Colecção:Artificial Cells, Nanomedicine, and Biotechnology
Assuntos:
Ventilator-induced lung injury
TRPM2 channel
NLRP3 inflammasome
IL-1β
IL-18
Acesso em linha:https://www.tandfonline.com/doi/10.1080/21691401.2019.1652631
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