PPARGC1A Gene Promoter Methylation as a Biomarker of Insulin Secretion and Sensitivity in Response to Glucose Challenges

Methylation in CpG sites of the PPARGC1A gene (encoding PGC1-α) has been associated with adiposity, insulin secretion/sensitivity indexes and type 2 diabetes. We assessed the association between the methylation profile of the PPARGC1A gene promoter gene in leukocytes with insulin secretion/sensitivi...

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Detalhes bibliográficos
Main Authors: José L. Santos, Bernardo J. Krause, Luis Rodrigo Cataldo, Javier Vega, Francisca Salas-Pérez, Paula Mennickent, Raúl Gallegos, Fermín I. Milagro, Pedro Prieto-Hontoria, J. Ignacio Riezu-Boj, Carolina Bravo, Albert Salas-Huetos, Ana Arpón, José E. Galgani, J. Alfredo Martínez
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-09-01
Colecção:Nutrients
Assuntos:
methylation
insulin sensitivity
insulin secretion
biomarker
gene variant
PPARGC1A gene
Acesso em linha:https://www.mdpi.com/2072-6643/12/9/2790
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