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Primary resistance to first-generation EGFR-TKIs induced by MDM2 amplification in NSCLC
Abstract Introduction Targeted therapy for NSCLC is rapidly evolving. EGFR-TKIs benefit NSCLC patients with sensitive EGFR mutations and significantly prolong survival. However, 20–30% of patients demonstrate primary resistance to EGFR-TKIs, which leads to the failure of EGFR-TKI treatment. The mech...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2020-07-01
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| Colecção: | Molecular Medicine |
| Assuntos: | |
| Acesso em linha: | http://link.springer.com/article/10.1186/s10020-020-00193-z |
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