Preparation and Characterization of Site-Specific Fatty Chain-Modified Recombinant Human Granulocyte Colony Stimulating Factor

The clinical use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) is limited by its short serum half-life. In this study, a long-acting strategy for site-specific modification of rhG-CSF with 1-pentadecyl-1H-pyrrole-2,5-dione (C15 fatty chain-maleimide, C15-MAL) was studied in mi...

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Detaylı Bibliyografya
Asıl Yazarlar: Xu-Dong Wang, Wei-Jia Yu, Jia-Hui Liu, Jie Du, Kang-Nan Chen, Qin-Qin Hu, Wen-Long Sun, Guo-Qing Ying
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2022-05-01
Seri Bilgileri:Frontiers in Bioengineering and Biotechnology
Konular:
rhG-CSF
recombinant human granulocyte colony stimulating factor
fatty chain
fatty chain modification
site-specific modification
thiol modification
Online Erişim:https://www.frontiersin.org/articles/10.3389/fbioe.2022.923059/full
Etiketler: Etiketle
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