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A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response
Abstract Human tauopathies including Alzheimer’s disease, progressive supranuclear palsy and related disorders, are characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. We have previously identified a pathogenic C-terminal tau fragment (Tau35) that is ass...
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| Autors principals: | , , , , |
|---|---|
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BMC
2019-01-01
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| Col·lecció: | Acta Neuropathologica Communications |
| Matèries: | |
| Accés en línia: | http://link.springer.com/article/10.1186/s40478-018-0651-9 |
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