Trabectedin – the DNA minor groove binder

Trabectedin (ET-743, Yondelis) is an alkaloid that was originally isolated from the Caribbean Sea squirt, Ecteinascidia turbinata and is now produced synthetically. Its chemical structure consists in three fused tetrahydroisoquinoline rings. Two of them, A and B, binds covalently to guanine residues...

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Main Authors: G. A. Belitsky, K. I. Kirsanov, E. A. Lesovaya, M. G. Yakubovskaya
Format: Artigo
Jezik:Russo
Izdano: ABV-press 2015-06-01
Serija:Uspehi Molekulârnoj Onkologii
Teme:
trabectedin
dna minor groove
ligand
malignant tumor
chemotherapy
dna repair
recombination
metabolism
hepatotoxicity
Online dostop:https://umo.abvpress.ru/jour/article/view/24
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