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The glycerol-3-phosphate dehydrogenases GpsA and GlpD constitute the oxidoreductive metabolic linchpin for Lyme disease spirochete host infectivity and persistence in the tick.

We have identified GpsA, a predicted glycerol-3-phosphate dehydrogenase, as a virulence factor in the Lyme disease spirochete Borrelia (Borreliella) burgdorferi: GpsA is essential for murine infection and crucial for persistence of the spirochete in the tick. B. burgdorferi has a limited biosyntheti...

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Autori principali: Dan Drecktrah, Laura S Hall, Bethany Crouse, Benjamin Schwarz, Crystal Richards, Eric Bohrnsen, Michael Wulf, Bonnie Long, Jessica Bailey, Frank Gherardini, Catharine M Bosio, Meghan C Lybecker, D Scott Samuels
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2022-03-01
Serie:PLoS Pathogens
Accesso online:https://doi.org/10.1371/journal.ppat.1010385
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