Expansion of the prime editing modality with Cas9 from Francisella novicida

Abstract Prime editing can induce a desired base substitution, insertion, or deletion in a target gene using reverse transcriptase after nick formation by CRISPR nickase. In this study, we develop a technology that can be used to insert or replace external bases in the target DNA sequence by linking...

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Main Authors: Yeounsun Oh, Wi-jae Lee, Junho K. Hur, Woo Jeung Song, Youngjeon Lee, Hanseop Kim, Lee Wha Gwon, Young-Hyun Kim, Young-Ho Park, Chan Hyoung Kim, Kyung-Seob Lim, Bong-Seok Song, Jae-Won Huh, Sun-Uk Kim, Bong-Hyun Jun, Cheulhee Jung, Seung Hwan Lee
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:Genome Biology
Assuntos:
Prime editing
Target expansion
CRISPR-Cas9
Ortholog
Francisella novicida
Acesso em linha:https://doi.org/10.1186/s13059-022-02644-8
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