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YAP-dependent Wnt5a induction in hypertrophic adipocytes restrains adiposity
Abstract Wnt5a, a prototypic non-canonical Wnt, is an inflammatory factor elevated in the sera of obese humans and mice. In the present study, fat-specific knockout of Wnt5a (Wnt5a-FKO) prevented HFD-induced increases in serum Wnt5a levels in male C57BL/6 J mice, which suggested adipocytes are prima...
שמור ב:
Main Authors: | , , , , , , , , |
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פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
Nature Publishing Group
2022-04-01
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סדרה: | Cell Death and Disease |
גישה מקוונת: | https://doi.org/10.1038/s41419-022-04847-0 |
תגים: |
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