The Drosophila hnRNP F/H Homolog Glorund Uses Two Distinct RNA-Binding Modes to Diversify Target Recognition

The Drosophila hnRNP F/H homolog, Glorund (Glo), regulates nanos mRNA translation by interacting with a structured UA-rich motif in the nanos 3′ untranslated region. Glo regulates additional RNAs, however, and mammalian homologs bind G-tract sequences to regulate alternative splicing, suggesting tha...

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Bibliographische Detailangaben
Hauptverfasser: Joel V. Tamayo, Takamasa Teramoto, Seema Chatterjee, Traci M. Tanaka Hall, Elizabeth R. Gavis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017-04-01
Schriftenreihe:Cell Reports
Schlagworte:
Glorund
nanos
Drosophila
hnRNP
hnRNP F
hnRNP H
RNA-binding protein
translational control
translational repressor
post-transcriptional regulation
development
Online Zugang:http://www.sciencedirect.com/science/article/pii/S221112471730339X
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