Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology

Abstract Background Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid progression of disease and lack of biomarkers. Magnetic resonance imaging (MRI) has demonstrated its potential for detec...

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Huvudupphovsmän: Menuka Pallebage-Gamarallage, Sean Foxley, Ricarda A. L. Menke, Istvan N. Huszar, Mark Jenkinson, Benjamin C. Tendler, Chaoyue Wang, Saad Jbabdi, Martin R. Turner, Karla L. Miller, Olaf Ansorge
Materialtyp: Artigo
Språk:Inglês
Publicerad: BMC 2018-03-01
Serie:BMC Neuroscience
Ämnen:
Amyotrophic lateral sclerosis
Magnetic resonance imaging
Post mortem brain
Systematic sampling
Histology
MRI-histology correlation
Länkar:http://link.springer.com/article/10.1186/s12868-018-0416-1
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