B Cells Are Critical to T-cell—Mediated Antitumor Immunity Induced by a Combined Immune-Stimulatory/Conditionally Cytotoxic Therapy for Glioblastoma

We have demonstrated that modifying the tumor microenvironment through intratumoral administration of adenoviral vectors (Ad) encoding the conditional cytotoxic molecule, i.e., HSV1-TK and the immune-stimulatory cytokine, i.e., fms-like tyrosine kinase 3 ligand (Flt3L) leads to T-cell-dependent tumo...

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Hlavní autoři: Marianela Candolfi, James F. Curtin, Kader Yagiz, Hikmat Assi, Mia K. Wibowo, Gabrielle E. Alzadeh, David Foulad, AKM G. Muhammad, Sofia Salehi, Naomi Keech, Mariana Puntel, Chunyan Liu, Nicholas R. Sanderson, Kurt M. Kroeger, Robert Dunn, Gislaine Martins, Pedro R. Lowenstein, Maria G. Castro
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2011-10-01
Edice:Neoplasia: An International Journal for Oncology Research
On-line přístup:http://www.sciencedirect.com/science/article/pii/S1476558611800825
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