NOTCH and DNA repair pathways are more frequently targeted by genomic alterations in inflammatory than in non‐inflammatory breast cancers

Inflammatory breast cancer (IBC) is the most pro‐metastatic form of breast cancer. Better understanding of its pathophysiology and identification of actionable genetic alterations (AGAs) are crucial to improve systemic treatment. We aimed to define the DNA profiles of IBC vs noninflammatory breast c...

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Hauptverfasser: François Bertucci, Charlotte Rypens, Pascal Finetti, Arnaud Guille, José Adélaïde, Audrey Monneur, Nadine Carbuccia, Séverine Garnier, Piet Dirix, Anthony Gonçalves, Peter Vermeulen, Bisrat G. Debeb, Xiaoping Wang, Luc Dirix, Naoto T. Ueno, Patrice Viens, Massimo Cristofanilli, Max Chaffanet, Daniel Birnbaum, Steven Van Laere
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley 2020-03-01
Schriftenreihe:Molecular Oncology
Schlagworte:
copy number profiling
DNA repair
inflammatory breast cancer
NOTCH
sequencing
targeted therapy
Online Zugang:https://doi.org/10.1002/1878-0261.12621
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