Enhancement of Aqueous Solubility and Dissolution of Celecoxib through Phosphatidylcholine-Based Dispersion Systems Solidified with Adsorbent Carriers

This study aimed to design phosphatidylcholine (PC)-based solid dispersion (SD) systems for enhancing the apparent aqueous solubility and dissolution of celecoxib (CLC), a selective cyclooxygenase-2 inhibitor with a highly hydrophobic property. Although PC-based dispersion formulations considerably...

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Auteurs principaux: Kanghee Jo, Jae Min Cho, Hyunjoo Lee, Eun Kyung Kim, Hong Chul Kim, Hyeongmin Kim, Jaehwi Lee
Format: Artigo
Langue:Inglês
Publié: MDPI AG 2018-12-01
Collection:Pharmaceutics
Sujets:
celecoxib
phosphatidylcholine
solid dispersion
solubility
dissolution rate
Accès en ligne:https://www.mdpi.com/1999-4923/11/1/1
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