Clinical validation of a next-generation sequencing-based multi-cancer early detection “liquid biopsy” blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study

Cancer is the leading cause of death in dogs, yet there are no established screening paradigms for early detection. Liquid biopsy methods that interrogate cancer-derived genomic alterations in cell-free DNA in blood are being adopted for multi-cancer early detection in human medicine and are now ava...

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Main Authors: Andi Flory, Kristina M. Kruglyak, John A. Tynan, Lisa M. McLennan, Jill M. Rafalko, Patrick Christian Fiaux, Gilberto E. Hernandez, Francesco Marass, Prachi Nakashe, Carlos A. Ruiz-Perez, Donna M. Fath, Thuy Jennings, Rita Motalli-Pepio, Kate Wotrang, Angela L. McCleary-Wheeler, Susan Lana, Brenda Phillips, Brian K. Flesner, Nicole F. Leibman, Tracy LaDue, Chelsea D. Tripp, Brenda L. Coomber, J. Paul Woods, Mairin Miller, Sean W. Aiken, Amber Wolf-Ringwall, Antonella Borgatti, Kathleen Kraska, Christopher B. Thomson, Alane Kosanovich Cahalane, Rebecca L. Murray, William C. Kisseberth, Maria A. Camps-Palau, Franck Floch, Claire Beaudu-Lange, Aurélia Klajer-Peres, Olivier Keravel, Luc-André Fribourg-Blanc, Pascale Chicha Mazetier, Angelo Marco, Molly B. McLeod, Erin Portillo, Terry S. Clark, Scott Judd, C. Kirk Feinberg, Marie Benitez, Candace Runyan, Lindsey Hackett, Scott Lafey, Danielle Richardson, Sarah Vineyard, Mary Tefend Campbell, Nilesh Dharajiya, Taylor J. Jensen, Dirk van den Boom, Luis A. Diaz, Daniel S. Grosu, Arthur Polk, Kalle Marsal, Susan Cho Hicks, Katherine M. Lytle, Lauren Holtvoigt, Jason Chibuk, Ilya Chorny, Dana W. Y. Tsui
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2022-01-01
Colecção:PLoS ONE
Acesso em linha:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041869/?tool=EBI
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