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Deletion of neural estrogen receptor alpha induces sex differential effects on reproductive behavior in mice

Neural deletion of the estrogen receptor, ERα, inhibits sexual behavior in female mice, but only has moderately effect in male mice. These results contrast with previous studies using global ERα knockouts, which found that ERα is mandatory for reproductive behavior in both sexes.

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Main Authors: Anne-Charlotte Trouillet, Suzanne Ducroq, Lydie Naulé, Daphné Capela, Caroline Parmentier, Sally Radovick, Hélène Hardin-Pouzet, Sakina Mhaouty-Kodja
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2022-04-01
Series:Communications Biology
Acceso en liña:https://doi.org/10.1038/s42003-022-03324-w
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