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Deletion of neural estrogen receptor alpha induces sex differential effects on reproductive behavior in mice

Neural deletion of the estrogen receptor, ERα, inhibits sexual behavior in female mice, but only has moderately effect in male mice. These results contrast with previous studies using global ERα knockouts, which found that ERα is mandatory for reproductive behavior in both sexes.

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Autors principals: Anne-Charlotte Trouillet, Suzanne Ducroq, Lydie Naulé, Daphné Capela, Caroline Parmentier, Sally Radovick, Hélène Hardin-Pouzet, Sakina Mhaouty-Kodja
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2022-04-01
Col·lecció:Communications Biology
Accés en línia:https://doi.org/10.1038/s42003-022-03324-w
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