TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription

Abstract We present TADsplimer, the first computational tool to systematically detect topologically associating domain (TAD) splits and mergers across the genome between Hi-C samples. TADsplimer recaptures splits and mergers of TADs with high accuracy in simulation analyses and defines hundreds of T...

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Detalhes bibliográficos
Main Authors: Guangyu Wang, Qingshu Meng, Bo Xia, Shuo Zhang, Jie Lv, Dongyu Zhao, Yanqiang Li, Xin Wang, Lili Zhang, John P. Cooke, Qi Cao, Kaifu Chen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-04-01
Colecção:Genome Biology
Assuntos:
Hi-C
Topologically associating domains
Chromatin conformation
Histone modification
Bioinformatics
Computational biology
Acesso em linha:http://link.springer.com/article/10.1186/s13059-020-01992-7
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