Nalaganje...
Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain
The use of siRNA-based therapies for the treatment of neurodegenerative disease requires efficient, nontoxic distribution to the affected brain parenchyma, notably the striatum and cortex. Here, we describe the synthesis and activity of a fully chemically modified siRNA that is directly conjugated t...
Shranjeno v:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier
2016-01-01
|
| Serija: | Molecular Therapy: Nucleic Acids |
| Teme: | |
| Online dostop: | http://www.sciencedirect.com/science/article/pii/S2162253117300677 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|