Differential expression of glial cell line-derived neurotrophic factor splice variants in the mouse brain

Glial cell line-derived neurotrophic factor (GDNF) plays a critical role in neuronal survival and function. GDNF has two major splice variants in the brain, α-pro-GDNF and β-pro-GDNF, and both isoforms have strong neuroprotective effects on dopamine neurons. However, the expression of the GDNF splic...

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Главные авторы: Xiao-He Gu, Heng Li, Lin Zhang, Tao He, Xiang Chai, He Wei, Dian-Shuai Gao
Формат: Artigo
Язык:Inglês
Опубликовано: Wolters Kluwer Medknow Publications 2020-01-01
Серии:Neural Regeneration Research
Предметы:
Δ78 locus; brain region; dopaminergic neurons; glial cell line-derived neurotrophic factor; mouse brain; precursor protein; α-pro-GDNF; β-pro-GDNF; sorting protein-related receptor with A-type repeats; splice variants
Online-ссылка:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=2;spage=270;epage=276;aulast=Gu
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