Effect of hydroxychloroquine and chloroquine on syncytial differentiation and autophagy in primary human trophoblasts

During placentation, cytotrophoblasts differentiate and fuse to form multinucleated cells (syncytiotrophoblasts) in a process that involves autophagy. Appropriate syncytial differentiation is essential for establishing a healthy pregnancy. In this study, we evaluated the effect of two chloroquine co...

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Hauptverfasser: Minji Choi, Nagyeong Byun, Jae Ryoung Hwang, Yun-Sun Choi, Ji-Hee Sung, Suk-Joo Choi, Jung-Sun Kim, Soo-young Oh, Cheong-Rae Roh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2022-05-01
Schriftenreihe:Biomedicine & Pharmacotherapy
Schlagworte:
Trophoblast
Differentiation
Syncytiotrophoblasts
Autophagy
Hydroxychloroquine
Chloroquine
Online Zugang:http://www.sciencedirect.com/science/article/pii/S0753332222003055
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