Identification of oleoylethanolamide as an endogenous ligand for HIF-3α

Whether hypoxia-inducible factors (HIFs) can be directly regulated by endogenous small molecules is a long-standing question. Here authors identified the metabolite oleoylethanolamide as a HIF-3α ligand and further revealed its mechanism of action.

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Bibliografiske detaljer
Main Authors: Xiaotong Diao, Fei Ye, Meina Zhang, Xintong Ren, Xiaoxu Tian, Jingping Lu, Xiangnan Sun, Zeng Hou, Xiaoyu Chen, Fengwei Li, Jingjing Zhuang, Hong Ding, Chao Peng, Fraydoon Rastinejad, Cheng Luo, Dalei Wu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2022-05-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/s41467-022-30338-z
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