Rearrangement of Immunoglobulin Genes in Tumor Cells of Patients with Primary Mediastinal (Thymic) Large B-Cell Lymphoma

Background. Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is a malignant tumor with large atypical lymphoid cells expressing post-germinal differentiation markers. Rearrangements of immunoglobulin genes in PMBCL are revealed in 30–65 % of cases. Immunoglobulin molecules, however, are ex...

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Auteurs principaux: YaK Mangasarova, YuV Sidorova, AU Magomedova, BV Biderman, EE Nikulina, AB Sudarikov, AM Kovrigina, SK Kravchenko
Format: Artigo
Langue:Russo
Publié: Practical Medicine Publishing House 2019-05-01
Collection:Kliničeskaâ onkogematologiâ
Sujets:
primary mediastinal (thymic) large b-cell lymphoma
rearrangement of immunoglobulin heavy/light chain genes
polymerase chain reaction
metachronous development of lymphoma
Accès en ligne: http://bloodjournal.ru/wp-content/uploads/2019/06/4.pdf
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