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Efficient Palladium-Catalyzed Synthesis of 2-Aryl Propionic Acids

A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (<b>9</b>) which enab...

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Autors principals: Helfried Neumann, Alexey G. Sergeev, Anke Spannenberg, Matthias Beller
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2020-07-01
Col·lecció:Molecules
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Accés en línia:https://www.mdpi.com/1420-3049/25/15/3421
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