DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation

Summary: DExD/H-box helicase members are key receptors for recognizing viral nucleic acids, and they regulate retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated type I interferon (IFN) production. Here, we report that the DExD/H-box helicase family member DExD/H-box RNA helicase 19...

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Hoofdauteurs: Kunli Zhang, Yuanfeng Zhang, Juan Xue, Qingwen Meng, Hongyang Liu, Caihong Bi, Changyao Li, Liang Hu, Huibin Yu, Tao Xiong, Yuying Yang, Shangjin Cui, Zhigao Bu, Xijun He, Jiangnan Li, Li Huang, Changjiang Weng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2019-01-01
Reeks:Cell Reports
Online toegang:http://www.sciencedirect.com/science/article/pii/S2211124719300385
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