HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression

Background: Quiescin sulfhydryl oxidase 1 (QSOX1), which oxidizes sulfhydryl groups to form disulfide bonds in proteins, is found to be over-expressed in various pancreatic cancer cell lines and patients. QSOX1 promotes invasion of pancreatic cancer cells by activating MMP-2 and MMP-9. However, its...

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Главные авторы: Chen-Ye Shi, Yue Fan, Bin Liu, Wen-Hui Lou
Формат: Artigo
Язык:Inglês
Опубликовано: Cell Physiol Biochem Press GmbH & Co KG 2013-08-01
Серии:Cellular Physiology and Biochemistry
Предметы:
Hypoxia
HIF-1
QSOX1
Matrix Metalloproteinase
Pancreatic Cancer Cell
Online-ссылка:http://www.karger.com/Article/FullText/354460
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