Gonadectomy in Mito-Ob mice revealed a sex-dimorphic relationship between prohibitin and sex steroids in adipose tissue biology and glucose homeostasis

Abstract Background Recently, we have developed a novel transgenic mouse model by overexpressing prohibitin (PHB) in adipocytes, which developed obesity due to upregulation of mitochondrial biogenesis in adipocytes, hence named “Mito-Ob.” Interestingly, only male Mito-Ob mice developed obesity-relat...

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Bibliographic Details
Main Authors: Yang Xin Zi Xu, Sudharsana Rao Ande, Suresh Mishra
Format: Artigo
Language:Inglês
Published: BMC 2018-08-01
Series:Biology of Sex Differences
Subjects:
Prohibitin
Obesity
Adipocyte differentiation
17β-estradiol
Testosterone
Sex differences
Online Access:http://link.springer.com/article/10.1186/s13293-018-0196-4
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