Natural Potent NAAA Inhibitor Atractylodin Counteracts LPS-Induced Microglial Activation

N-acylethanolamine-hydrolyzing acid amidase (NAAA) is a lysosomal enzyme that inhibits the degradation of palmitoylethanolamide (PEA), an endogenous lipid that induces analgesic, anti-inflammation, and anti-multiple sclerosis through PPARα activation. Only a few potent NAAA inhibitors have been repo...

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Detalhes bibliográficos
Main Authors: Longhe Yang, Chunyan Ji, Yitian Li, Fan Hu, Fang Zhang, Haiping Zhang, Long Li, Jie Ren, Zhaokai Wang, Yan Qiu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-10-01
Colecção:Frontiers in Pharmacology
Assuntos:
NAAA inhibitor
atractylodin
anti-inflammation
microglia
traditional Chinese medicine
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphar.2020.577319/full
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