Inactivation of a Mismatch-Repair System Diversifies Genotypic Landscape of Escherichia coli During Adaptive Laboratory Evolution

Adaptive laboratory evolution (ALE) is used to find causal mutations that underlie improved strain performance under the applied selection pressure. ALE studies have revealed that mutator populations tend to outcompete their non-mutator counterparts following the evolutionary trajectory. Among them,...

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Main Authors: Minjeong Kang, Kangsan Kim, Donghui Choe, Suhyung Cho, Sun Chang Kim, Bernhard Palsson, Byung-Kwan Cho
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-08-01
Colecção:Frontiers in Microbiology
Assuntos:
adaptive laboratory evolution
mismatch repair
Escherichia coli
genotype space
phenotype microarray
Acesso em linha:https://www.frontiersin.org/article/10.3389/fmicb.2019.01845/full
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